ODCs

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2 OMIM references -
2 associated genes
10 signs/symptoms

COMMON GENES: 1
PROTEIN INTERACTIONS: 1
COMMON SIGNS: 9

1 OMIM reference -
1 associated gene
14 signs/symptoms

Hyperostosis corticalis generalisata

Autosomal dominant osteosclerosis, Worth type

LRP5	(UniProt - OMIM)		LRP5	(UniProt - OMIM)
SOST	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	SOST	(0.68)	LRP5

Citations in the biomedical literature:

Hyperostosis corticalis generalisata		Autosomal dominant osteosclerosis, Worth type
	Synonym(s): - Van Buchem disease		Synonym(s): - Endosteal hyperostosis, Worth type - Worth syndrome

	Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare genetic disease		Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare genetic disease

	Classification (ICD10): - Diseases of the musculoskeletal system and connective tissue -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: - Average age onset: - Average age of death: - Type of inheritance: autosomal recessive		Epidemiological data: Class of prevalence: - Average age onset: - Average age of death: - Type of inheritance: autosomal dominant

	External references: 2 OMIM references - No MeSH references		External references: 1 OMIM reference - No MeSH references


COMMON SIGNS	- Clavicle absent / abnormal - Cortical anomaly / thick bone cortical layer - Dense / thickened skull / calvarium / cranial / facial hyperostosis - Enlarged diaphysis / diaphyses - Enlargment of jaw / large jaw - Facial palsy - Osteosclerosis / osteopetrosis / bone condensation - Prognathism / prognathia - Sensorineural deafness / hearing loss

Hyperostosis corticalis generalisata		Autosomal dominant osteosclerosis, Worth type
	Very frequent - Autosomal recessive inheritance		Very frequent - Anomalies of the ribs - Autosomal dominant inheritance - Palate exostoses / torus palatinus Frequent - Abnormal vertebral size / shape Occasional - Nystagmus